The enigma of monosomy 7

Defective neutrophil migration in monosomy-7.

The migration in vitro of neutrophils from six patients with monosomy-7 or partial deletion of the long arm of chromosome 7 was studied by two methods: the Millipore filter assay and the migration under agarose assay. Four of the patients had preleukemia, one had subacute myelomonocytic leukemia, and one polycythemia vera. In four patients, chemotaxis (migration towards a higher concentration o...

Mutations of the ras proto-oncogenes in childhood monosomy 7.

ras gene mutations are the most frequent molecular changes found in the preleukemic syndromes of adults and may play a role in initiating these diseases and in their progression to acute leukemia. However, little is known about the incidence or importance of these genetic mutations in childhood myeloproliferative states (MPS). The bone marrow (BM) monosomy 7 syndrome accounts for a large percen...

Myeloproliferative syndrome of monosomy 7: A brief report

We report the case of a five-month-old black male infant who had recurrent episodes of respiratory infections and also presented anemia and enlargements of the spleen, liver and lymphnodes. Hematological analysis revealed morphological abnormalities with megaloblastic dyserythropoiesis, while fetal hemoglobin assaying showed normal levels. Conventional and molecular cytogenetic analysis reveale...

Childhood monosomy 7: epidemiology, biology, and mechanistic implications.

G-CSF and monosomy 7 in marrow failure patients

Kojima and colleagues (page 786) report a correlation between G-CSF treatment of children with aplastic anemia and evolution to cytogenetic abnormalities and myelodysplasia. How strong is this relationship and how generalizable the conclusions? The Japanese investigators administered high G-CSF doses (close to the adult equivalent of 10 g/kg/d, later thrice weekly) for very long periods (in all...